For the first time in the UK, families with thalassemia-affected children can envision a future free from chronic illness, thanks to British-Pakistani paediatric consultant Dr. Sher Bahadur Anjum.
Dr. Anjum, a haematology specialist at Newham Hospital in East London (part of Barts Health NHS Trust), led a team that successfully treated two boys of Bangladeshi background, now aged 11 and 13, using cutting-edge gene therapy. The treatment has restored their lives to complete normality no more monthly hospital visits or blood transfusions.
Thalassemia, a genetic blood disorder common in Pakistani, Indian, and Bangladeshi communities, causes low iron and oxygen levels, leading to severe anaemia, fatigue, shortness of breath, and pallor. Previously, the boys relied on regular transfusions, severely impacting their quality of life. The only traditional cure stem cell or bone marrow transplant carries high risks and donor challenges.
Partnering with Great Ormond Street Hospital (GOSH), Dr. Anjum's team delivered the innovative therapy. Pre-treatment at Newham involved three months of intensive preparation: blood tests, vaccinations, and haemoglobin stabilization. The four-week GOSH procedure was followed by ongoing monitoring for side effects and blood counts.
Originally from Gilgit-Baltistan's Astoria village and educated at Abbottabad Medical College, Dr. Anjum faced initial family hesitation due to the therapy's novelty and extended hospital stay. After nearly 12 months of patient discussions, reassurance, and trust-building, both families agreed. Dr. Anjum secured an honorary contract at GOSH to support them throughout.
Explaining the breakthrough to Geo News, Dr. Anjum said: "Gene therapy targets the root cause. We extract a child's blood stem cells, insert a healthy haemoglobin gene, and reinfuse them. The body then produces its own haemoglobin, eliminating transfusion needs a success in many cases."
"These boys grew up defined by hospital routines; their parents endured endless emotional and logistical burdens," he added. "When Barts Health joined the NHS gene therapy program, we seized the chance. Convincing families took a year of empathy amid their fears. Six months post-treatment, the boys are thrivingfull of energy, with bright futures ahead."
Dr. Anjum urges eligible South Asian parents: "This transforms despair into hope, showcasing NHS collaboration with patients at its core. If your doctor recommends it, embrace the opportunity."
